SIPI — 100 Questions Mind Map

SIPI 100 Questions topic map

Lifespan & Cognition (6 clusters, 21 questions)

Prevention & Metabolic Health
- Which population-level dietary and activity interventions reduce cardiometabolic risk in Swiss working-age adults?
- How does air quality variation across Swiss cantons correlate with cardiometabolic risk trajectories?
- What biomarker combination best predicts 10-year cardiometabolic risk in Swiss midlife populations?
- Can claims data combined with GP records identify high-risk individuals 3–5 years before hospitalisation?
Brain Capital & Mental Health
- What occupational stressors best predict burnout-related sick leave in Swiss healthcare workers?
- What validated tools distinguish stress-related cognitive symptoms from neurodegenerative patterns?
- Can GP records, wearables, and claims analytics identify MCI 2–4 years before presentation?
- What proportion of burnout absence is preceded by detectable cognitive load signals in the prior 6 months?
Frailty & Functional Independence
- Which clinical markers best predict frailty onset in 60–75 year olds in Swiss integrated care settings?
- Can hospital discharge data identify patients on frailty trajectories before first avoidable readmission?
- What is the economic return on a 1-year delay in frailty onset?
- Which community-based interventions most effectively delay dependency in 70–80 year olds?
Care Models & Integrated Pathways
- What proportion of emergency psychiatric presentations could have been averted with earlier stepped-care?
- What design features of Swiss integrated care pilots most consistently reduce avoidable hospitalisation?
- What reimbursement structures most effectively incentivise prevention-oriented practice without cream-skimming?
Digital Health & AI
- What proportion of clinician documentation time can be recovered through AI tools without quality loss?
- What governance safeguards are necessary for AI risk stratification in Swiss primary care?
- Can federated AI models trained on Swiss hospital data identify risk signals invisible to individual sites?
Health System Financing
- What evidence threshold do insurers require to participate in shared-savings for prevention in Switzerland?
- Which LAMal revision levers have greatest potential to shift incentives toward prevention?
- What is the expected ROI of CHF 1M in prevention infrastructure at Lighthouse Region scale over 10 years?

Food & Nutrition (6 clusters, 18 questions)

True Cost Accounting & Food Economics
- What minimum true cost indicators can food companies credibly report without new data collection?
- How does the true cost differential between healthy and unhealthy convenient food vary across Swiss income deciles?
- Can a standardised health-adjusted earnings metric for Swiss food companies be derived from existing datasets?
Dietary Patterns & Metabolic Outcomes
- What dietary pattern data best predicts cardiometabolic risk in Swiss 40–60 year olds?
- What is the DALY reduction attributable to a 10% improvement in dietary quality across the Swiss working-age population?
- Does nutritional density predict frailty onset trajectory independent of physical activity in 60–75 year olds?
Gut, Inflammation & Brain Health
- Does dietary pattern in Swiss midlife predict cognitive trajectory independent of cardiometabolic risk?
- What dietary biomarkers most reliably predict neuroinflammation risk in 50–70 year olds?
- Can gut microbiome composition serve as an actionable early indicator of cognitive vulnerability in primary care?
Soil Health & Nutritional Quality
- What agricultural practices in Swiss cantons most reliably improve nutritional density of food produced?
- Is there a measurable difference in mineral density between Swiss organic and conventional food?
- What cantonal agricultural subsidy levers best incentivise higher nutritional density production?
Food Environments & Behaviour
- Under what conditions do choice architecture interventions produce durable dietary change?
- What employer subsidy reallocation designs most effectively shift cafeteria purchasing toward nutritious options?
- Can Digital Product Passports displaying true cost change procurement decisions by institutional buyers?
Prevention Finance & Food Investment
- What is the cost-of-illness reduction from measurable dietary quality improvement over 10 years?
- Under what conditions would Swiss insurers participate in shared-savings linked to dietary improvements?
- What nutritional interventions most effectively reduce sarcopenia risk in 65–80 year olds?

SFNV ecosystem (8 clusters, 24 questions)

Food Innovation & Entrepreneurship
- Startup ecosystem. Incubation and acceleration programmes for Swiss food tech startups
  - FoodTech accelerator programmes
  - Deep-tech food venture funding
  - Corporate-startup co-innovation models
- Scale-up pathways. Market access and internationalisation for Swiss food innovators
  - EU market entry frameworks
  - Retail and foodservice channel access
  - Export support for Swiss food SMEs
- Open innovation. Collaborative R&D between industry, academia, and SMEs
  - Cross-sector IP and co-ownership models
  - Challenge-based innovation sprints
  - Innovation procurement by large food corporates
Nutritional Science & Health Claims
- Nutrient bioavailability. How food processing and preparation affect nutrient absorption and efficacy
  - Matrix effects on micronutrient absorption
  - Fermentation and bioavailability enhancement
  - Fortification strategies for vulnerable populations
- Health claims regulation. EFSA and Swiss substantiation pathways for nutrition and health claims
  - Clinical evidence requirements for claims
  - Authorised vs general function claims
  - Novel food regulation EU 2015/2283
- Personalised nutrition. Individual-level dietary recommendations based on genetics, microbiome, and lifestyle data
  - Nutrigenomics and polygenic risk scores
  - Microbiome-informed dietary guidance
  - Digital platforms for personalised meal planning
Food Systems Sustainability
- Environmental footprint. Life cycle assessment and planetary boundaries in Swiss food production
  - Scope 3 emissions in Swiss food supply chains
  - Water footprint of livestock vs plant protein
  - Biodiversity impact assessment frameworks
- Alternative proteins. Plant-based, fermentation-derived, and cultivated protein sources for the Swiss market
  - Consumer acceptance of alternative proteins in CH
  - Regulatory pathway for precision-fermented ingredients
  - Hybrid products bridging conventional and alternative
- Food waste reduction. Interventions reducing food loss across the Swiss supply chain
  - Dynamic pricing and surplus redistribution platforms
  - Packaging innovation for shelf-life extension
  - Dynamic product passports for remaining shelf-life
Digital Food Technology
- AI & data in food. Machine learning applications across the food value chain from farm to consumer
  - AI-driven formulation and product development
  - Predictive quality control in manufacturing
  - Consumer behaviour modelling from purchase data
- Traceability & transparency. Blockchain, IoT, and digital passports for food origin and quality verification
  - Digital Product Passports — nutrition and origin
  - Farm-to-fork traceability standards
  - Consumer-facing transparency interfaces
- Precision fermentation. Microbial engineering for ingredients, flavours, and functional nutrients at commercial scale
  - Scale-up economics of precision fermentation
  - Regulatory approval timeline in Switzerland and EU
  - Consumer communication strategies for novel ingredients
Health & Prevention
- Diet-disease prevention. Evidence-based dietary strategies for chronic disease prevention in Swiss populations
  - Mediterranean and MIND diet evidence in Swiss context
  - Ultra-processed food consumption and chronic disease risk
  - Sugar reduction — reformulation and policy approaches
- Gut health & immunity. Microbiome, prebiotics, and immune function — evidence and product development implications
  - Clinical evidence for probiotics in Swiss populations
  - Prebiotic fibre and metabolic health outcomes
  - Microbiome diversity as a population health endpoint
- Cognitive performance nutrition. Nutritional strategies supporting brain function, focus, and stress resilience
  - Omega-3 and cognitive trajectory evidence
  - Adaptogenic ingredients and stress biomarkers
  - Nutritional support for clinical workforce cognitive load
Ingredients & Processing
- Functional ingredients. Bioactive compounds with demonstrated health-promoting properties and market potential
  - Polyphenols, flavonoids, and cardiovascular outcomes
  - Omega-3 sources: algae, marine, and plant-based
  - Adaptogens and stress-modulating ingredients
- Clean label & minimal processing. Reformulation strategies meeting consumer demand for shorter ingredient lists
  - NOVA classification and reformulation strategy
  - Natural preservation methods and shelf stability
  - Texture and taste maintenance in reformulated products
- Swiss terroir & heritage. Regional Swiss ingredients and traditional food knowledge in modern applications
  - AOP/IGP designations and premium market positioning
  - Revitalising traditional Swiss fermented foods
  - Swiss alpine botanicals in functional food applications
Policy, Regulation & Standards
- Swiss food law. LDAl, OSAV, and regulatory frameworks governing food products in Switzerland
  - Mutual recognition of EU food standards in CH
  - Front-of-pack labelling reform — NutriScore debate
  - Organic and sustainability certification standards
- Public health nutrition policy. BAG, cantonal health offices, and national dietary recommendations in practice
  - Swiss Food Pyramid and evidence update cycles
  - School food standards and procurement mandates
  - Incentive-based vs regulatory approaches to diet change
- EU Green Deal & Farm to Fork. Switzerland's positioning relative to the EU food system transformation agenda
  - CH-EU agricultural alignment — post-Brexit analogy
  - Pesticide reduction targets and Swiss equivalence
  - Sustainable food procurement in public institutions
Education, Talent & Ecosystem
- Workforce & skills. Education pipelines and skills gaps across the Swiss food innovation sector
  - Food tech curricula at ETHZ, ZHAW, Agroscope
  - Industry-academia joint degree and secondment models
  - Multilingual talent in the Swiss food corridor
- Cluster & network development. SFNV's role in convening and internationalising the Swiss food ecosystem
  - Cross-cluster connections: medtech, pharma, agtech
  - International positioning — Lausanne/Bern/Zurich corridor
  - Alumni and mentor networks for food founders
- Consumer engagement & trust. Building public understanding and trust in food innovation and novel ingredients
  - Science communication on novel food technologies
  - Co-creation and citizen involvement in food R&D
  - Combating food misinformation in Swiss media

Cross-programme (4 clusters, 11 questions)

Diet, Cognition & Frailty
- Does dietary pattern in Swiss midlife predict cognitive decline onset in 55–70 year olds, independent of cardiometabolic risk?
- Does nutritional density predict frailty onset trajectory independent of physical activity in 60–75 year olds?
- What nutritional interventions most effectively reduce sarcopenia risk in 65–80 year olds in Swiss community settings?
Cardiometabolic Risk & Dietary Biomarkers
- What dietary biomarkers most reliably predict cardiometabolic risk trajectories in Swiss 40–60 year olds at population scale?
- Which biomarkers are most responsive to dietary pattern change in 45–65 year olds, and over what timeframe?
Prevention Finance: Shared Investment Case
- What is the combined cost-of-illness reduction from simultaneous improvement in dietary quality and prevention-oriented care over 10 years?
- How should savings be attributed across actors in a shared-savings arrangement spanning clinical and food environment prevention?
- How can a single blended capital structure fund both Lighthouse Regions and food demonstrators with coherent milestone definitions?
Shared Data Infrastructure
- What governance architecture enables one federated collaborative to serve clinical health outcomes and food environment analytics without conflating their privacy requirements?
- Can cantonal agricultural datasets be made interoperable with health outcome datasets under existing Swiss law?
- What minimum data standard across cantonal agricultural offices enables cross-cantonal comparison while preserving data sovereignty?

SIPI · 100 Questions Topic Map · 2026